This listing was posted on jobRxiv.
Senior Scientist, Neuroscience
Location:
London, Gt Lon
Description:
Job DescriptionOur company has a rapidly growing interdisciplinary team of scientists in London and exciting plans to expand our London presence, initially at the Francis Crick Institute as part of our 'Skylab' expansion in 2024, and from 2027 in our new 'state of art' and fully integrated Research and Discovery Center at the hub of London's knowledge Quarter, which will be home to approximately 180 scientists alongside other colleagues in discovery research, clinical, regulatory and business roles, including marketing, finance and administration.Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines through improving our understanding of how our potential new therapies and medicines work at a cellular and molecular level in the patients we serve.Our London Discovery Centre is seeking a passionate and driven candidate to join our Neuroscience team based at the London Bioscience Innovation Centre (LBIC) in St. Pancras, London. The candidate for this Senior Scientist position will contribute to cutting-edge discovery biology research with a focus on investigating age-related neurodegeneration and should have strong expertise in the underlying mechanisms of neurodegeneration including oxidative or ER stress. You will join a highly collaborative, multi-disciplinary research team. You will collaborate and interact with scientists across groups within our company, who have extensive experience in neurodegeneration, cellular biology, in vitro pharmacology, chemistry, and data science. Responsibilities include but are not limited to: Design, implement and perform in vitro experiments to investigate oxidative stress and ER stress mechanisms and pathways to support the development of early potential drug candidates Design and implement novel disease-relevant in vitro models to evaluate the impact of oxidative and ER stress on cellular and molecular functions Develop and validate novel techniques and assays relevant to oxidative and ER stress research Keep up to date with advancements in the field of oxidative and ER stress research and apply relevant knowledge to enhance experimental approaches Collaborate with members from other functional areas, including medicinal chemistry, in vivo and in vitro pharmacology, imaging, genetics and translational sciences to drive progress Timely write-up of reports and data analysis Oral and written communication of data in a clear and concise manner to the appropriate teams and stakeholders Education & Experience Minimum Requirements: Recently completed PhD, or BSc or MSc in a life sciences discipline (Neuroscience, Biochemistry, or related discipline) with some pharmaceutical industry experience if PhD qualified, and significant experience if BSc or MSc qualified Required Experience and Skills: Expertise in cell culture techniques working with primary cells, cell lines, and iPSCs Expertise in molecular biology and microscopy/cellular imaging techniques Excellent attention to detail in experimental design and data analysis Strong interpersonal, verbal, and written communication skills Ability to thrive within a matrixed organization and collaborate with cross-functional teams Experience in any of the following would be advantageous: Strong scientific understanding of mechanisms of neurodegeneration including oxidative stress or ER stress Expertise in in vitro models of oxidative & ER stress, including developing and running assays for ROS measurement, antioxidant assays and cellular stress assays Proficiency in a range of cellular and molecular biology techniques Cell imaging and microscopy including high content imaging. Demonstrated knowledge of drug discovery and assay development Expertise in operating high throughput instrumentation, including plate readers and liquid handling instrumentation Closing date for applications: 7th May 2024Current Employees apply HERECurrent Contingent Workers apply HERE Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Regular Relocation: VISA Sponsorship: Travel Requirements: Flexible Work Arrangements: Not Applicable Shift: Valid Driving License: Hazardous Material(s):
Company:
Merck
Posted:
April 28 on jobRxiv
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More About this Listing: Senior Scientist, Neuroscience
Senior Scientist, Neuroscience is a Science & Pharmaceutical Scientist Job at Merck located in London LND. Find other listings like Senior Scientist, Neuroscience by searching Oodle for Science & Pharmaceutical Scientist Jobs.
Senior Scientist, Neuroscience is a Science & Pharmaceutical Scientist Job at Merck located in London LND. Find other listings like Senior Scientist, Neuroscience by searching Oodle for Science & Pharmaceutical Scientist Jobs.