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PhD position in Cancer Cell Mechanobiology | Phd in Job Job at Department of Biomedical Engineerin1

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PhD position in Cancer Cell Mechanobiology

Location:
Glasgow, Glasgow
Description:

Research project title and framework (Inter)Facing mechanotransduction-related aspects of brain tumour cell metastasis and therapeutic resistance Background Nowadays, it becomes increasingly evident that it is not sufficient to only look at genetic and biochemical factors to fully understand brain cancer and metastases, but that also mechanical aspects of the cells and their extracellular matrix need to be considered. This holds particularly true with respect to the outcome of related cancer treatments.Mechanotransduction; i.e., a force-based dialogue between cell and microenvironment that converts biophysical cues into cellular responses, has been identified as an essential mechanisms therein. Project The interdisciplinary project aspires to dissect the mechanotransduction-related events in the brain cancer cell/microenvironment interface and their contribution to brain cancer (such as glio- and medulloblastoma) pathophysiology and therapeutic resistance. The approach will comprise, e.g., biomaterials and advanced bioimaging techniques to detect changes along the mechanotransductive sequence related to biophysical cues in the cellular microenvironment, as well as alterations in response to therapeutic treatments. Research environment The student will benefit from the integration into the established interdisciplinary research environment at the Department of Biomedical Engineering of the University of Strathclyde Glasgow and the Centre for the Cellular Microenvironment, with versatile experience in providing expertise and training for such projects at the intersection between cell biology, oncology, pharmacology, physics and engineering. Informal enquiries are welcomed , please get in touch if you have any questions. How to apply?: If you are already sure that this opportunity could interest you, please send the following documents by 31st May 2024 to the e-mail that you find after clicking on “Apply”:(1) a CV (2 pages maximum); please include details of two references for the assessment of your application.(2) a cover letter highlighting candidate’s background (skills, experience, and research interests); how these make the candidate suitable for this position (1 page max).(3) a copy of academic transcript. Additional info: Funding is secured for home students. To be classed as a home student, applicants must meet one the following criteria:· Be a UK national (meeting residency requirements),· Have settled status,· Have pre-settled status (meeting residency requirements),· Have indefinite leave to remain or enter.If a student does not meet the criteria above, they will be classed as an international student. The international portion of the tuition fee cannot be funded by the grant and must be covered from other sources. International students are permitted to self-fund the difference between the home and international fee rates.
Company:
Department Of Biomedical Engineering Of The University Of
Posted:
May 7 on jobRxiv
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